Rapid Determination of Enantiomeric Excess via NMR Spectroscopy: A Research-Informed Experiment
نویسندگان
چکیده
منابع مشابه
Well Plate Circular Dichroism Reader for the Rapid Determination of Enantiomeric Excess.
Circular dichroism (CD) spectropolarimeters typically employ one photoelastic modulator. However, spectropolarimeters employing two or even four modulators are more versatile and can be used to subvert common measurement errors arising from imperfectly isotropic samples or sample holders. Small linear anisotropies that can cause large errors in CD measurement can be associated with multi-well s...
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متن کاملFirst principles design of derivatizing agent for direct determination of enantiomeric purity of chiral alcohols and amines by NMR spectroscopy.
(77)Se NMR offers superior sensing of chirality within the structure of the diastereomers (Deltadelta up to 6.1 ppm), compared to (13)C (Deltadelta < 1 ppm) and (1)H (Deltadelta < 0.2 ppm). The developed procedure is equally well suitable for determination of the enantiomeric purity of chiral alcohols and amines as pure samples as well as reaction mixtures and crude products.
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ژورنال
عنوان ژورنال: Journal of Chemical Education
سال: 2016
ISSN: 0021-9584,1938-1328
DOI: 10.1021/acs.jchemed.6b00355